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  •  Levocloperastine Hcl : It is a cough suppressant. It is a novel antitussive with a pharmacological profile distinct from that of the racemic DL-cloperastine. Levocloperastine with its dual mechanism of action acts on both the central bulbar cough centre and on peripheral receptors in the tracheobronchial tree.

Indications: It is indicated for the treatment of non-productive cough in adult patients.

Dose and administration: The usual recommended dose is 20mg three times a day.

Contraindications: It is contraindicated in patients with hypersensitivity to any ingredients of the formulation. Patients with excessive discharge of mucus and limited mucciliary function, severe liver impairment and child < 1 year.

Warning and precautions: Hypertension, cardiovascular disease, uncontrolled diabetes mellitus, hyperthyroidism, seizures or patients who are unusually hypertensive to sympathomimetic amines.

Pregnancy and Lactation: Safety of levocloperastine has not been studied in pregnancy and lactation. Therefore, probable benefits should be weighed against possible risks.

Interactions: Levocloperastine should not be concomitantly prescribed with sedative or tranquilizer drugs. Similarly, other antihistamine drugs should not be prescribed concomitantly. Alcohol is strictly contraindicated.

Adverse reactions: It is generally well tolerated, with mild and transient nausea the only adverse event reported. There has been no evidence of central adverse events with levocloperastine, whereas levodropropizine, codeine and DLcloperastine caused drowsiness in a number of patients. No significant changes in laboratory respiratory/cardiovascular/ haematological parameters were observed. Dryness of mouth, dizziness might be expected. Minor and transient adverse reactions are GI effects, exhaustion, faintness, somnolence, clouding of consciousness, numbness, dizziness, headache, palpitations.

Brand Name

Composition

Company

Packing

MRP
Rs.

LUPITUSS oral susp

Levocloperastine fendizoate 35.4mg equivalent to Levocloperastine hcl 20mg per 5ml

LUPIN

60ml

45.33

LUPITUSS oral susp

Levocloperastine fendizoate 35.4mg equivalent to Levocloperastine hcl 20mg per 5ml

LUPIN

100ml

79.50

 

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